SB939 ( Pracinostat )
Catalog No. A10830
SB939 (Pracinostat)是HDAC的口服抑制剂,对I,II和IV类HDAC具有选择性,在体外HDAC1活性测定中显示IC50值为77 nM。
- Giovanni Bocci, .et al. Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19, ACS Pharmacol Transl Sci, 2020, Oct 14
Catalog Num | A10830 |
---|---|
M. Wt | 358.5 |
Formula | C20H30N4O2 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 929016-96-6 |
Synonyms | Pracinostat, SB-939 |
SMILES | CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)/C=C/C(=O)NO |
SB939 (Pracinostat)是HDAC的口服抑制剂,对I,II和IV类HDAC具有选择性,在体外HDAC1活性测定中显示IC50值为77 nM。
Targets
Target | Value |
---|---|
HDAC10 | IC50: 40nM |
HDAC3 | IC50: 43nM |
HDAC5 | IC50: 47nM |
HDAC1 | IC50: 49nM |
HDAC4 | IC50: 56nM |
HDAC9 | IC50: 70nM |
HDAC11 | IC50: 93nM |
HDAC2 | IC50: 96nM |
HDAC7 | IC50: 137nM |
HDAC8 | IC50: 140nM |
HDAC6 | IC50: 1.008μM |
SIRT1 | IC50: >100μM |
In vitro (25°C) | DMSO | 68 mg/mL (189.68 mM) | |
Water | Insoluble | ||
Ethanol | 26 mg/mL (72.52 mM) | ||
In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 27.89 mL | 139.47 mL | 278.94 mL |
0.5 mM | 5.58 mL | 27.89 mL | 55.79 mL |
1 mM | 2.79 mL | 13.95 mL | 27.89 mL |
5 mM | 0.56 mL | 2.79 mL | 5.58 mL |
*The above data is based on the productmolecular weight 358.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.