SB939 ( Pracinostat )

Catalog No. A10830

SB939 (Pracinostat)是HDAC的口服抑制剂,对I,II和IV类HDAC具有选择性,在体外HDAC1活性测定中显示IC50值为77 nM。
  • Giovanni Bocci, .et al. Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19, ACS Pharmacol Transl Sci, 2020, Oct 14
Catalog Num A10830
M. Wt 358.5
Formula C20H30N4O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 929016-96-6
Synonyms Pracinostat, SB-939
SMILES CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)/C=C/C(=O)NO
SB939 (Pracinostat)是HDAC的口服抑制剂,对I,II和IV类HDAC具有选择性,在体外HDAC1活性测定中显示IC50值为77 nM。
Targets
Target Value
HDAC10IC50: 40nM
HDAC3IC50: 43nM
HDAC5IC50: 47nM
HDAC1IC50: 49nM
HDAC4IC50: 56nM
HDAC9IC50: 70nM
HDAC11IC50: 93nM
HDAC2IC50: 96nM
HDAC7IC50: 137nM
HDAC8IC50: 140nM
HDAC6IC50: 1.008μM
SIRT1IC50: >100μM
In vitro (25°C) DMSO 68 mg/mL (189.68 mM)
Water Insoluble
Ethanol 26 mg/mL (72.52 mM)
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.89 mL 139.47 mL 278.94 mL
0.5 mM 5.58 mL 27.89 mL 55.79 mL
1 mM 2.79 mL 13.95 mL 27.89 mL
5 mM 0.56 mL 2.79 mL 5.58 mL

*The above data is based on the productmolecular weight 358.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.