SGX-523

Catalog No. A10839

SGX-523是一种口服生物可利用的小分子，与c-Met蛋白或HGFR特异性结合，可防止HGF结合并破坏MET信号通路。

Technical details

Catalog Num	A10839
M. Wt	359.4
Formula	C18H13N7S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1022150-57-7
Synonyms	SGX523
SMILES	CN1C=C(C=N1)C2=NN3C(=NN=C3SC4=CC5=C(C=C4)N=CC=C5)C=C2

Biological Activity

SGX-523是一种口服生物可利用的小分子，与c-Met蛋白或HGFR特异性结合，可防止HGF结合并破坏MET信号通路。

Targets

Target	Value
c-Met	IC50: 4nM
B-Raf(V599E)	IC50: >7μM
C-Raf	IC50: >7μM
Abl	IC50: >7μM
p38α	IC50: >7μM
Abl1(Y253F)	IC50: >7μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 3 mg/mL (8.34 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% methylcellulose+0.2% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.82 mL	139.12 mL	278.24 mL
0.5 mM	5.56 mL	27.82 mL	55.65 mL
1 mM	2.78 mL	13.91 mL	27.82 mL
5 mM	0.56 mL	2.78 mL	5.56 mL

*The above data is based on the productmolecular weight 359.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.