SNS-032 (BMS-387032)

Catalog No. A10850

SNS-032（BMS-387032）是细胞周期蛋白依赖性激酶（Cdks）2、7和9的高度选择性和有效抑制剂，具有体外生长抑制作用，并具有诱导恶性B细胞凋亡的能力。

Technical details

Catalog Num	A10850
M. Wt	380.5
Formula	C17H24N4O2S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	345627-80-7
Synonyms	SNS032, BMS-387032, BMS387032
SMILES	CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3

Biological Activity

SNS-032（BMS-387032）是细胞周期蛋白依赖性激酶（Cdks）2、7和9的高度选择性和有效抑制剂，具有体外生长抑制作用，并具有诱导恶性B细胞凋亡的能力。

Targets

Target	Value
CDK9/CyclinT	IC50: 4nM
CDK2/CyclinA	IC50: 38nM
CDK2/CyclinE	IC50: 48nM
CDK7/CyclinH	IC50: 62nM
GSK-3α	IC50: 230nM
CDK5/p35	IC50: 340nM
CDK1/CyclinB	IC50: 480nM
GSK-3β	IC50: 660nM
CDK4/CyclinD	IC50: 925nM
CDK6/CyclinD	IC50: >1μM

Solubility *

In vitro (25°C)	DMSO	74 mg/mL (194.46 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.28 mL	131.41 mL	262.81 mL
0.5 mM	5.26 mL	26.28 mL	52.56 mL
1 mM	2.63 mL	13.14 mL	26.28 mL
5 mM	0.53 mL	2.63 mL	5.26 mL

*The above data is based on the productmolecular weight 380.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.