SU11274

Catalog No. A10869

SU11274是一种Met酪氨酸激酶抑制剂。

Technical details

Catalog Num	A10869
M. Wt	568.1
Formula	C28H30CIN5O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	658084-23-2
Synonyms	SU-11274, PKI-SU11274
SMILES	CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)/C=C\3/C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O

Biological Activity

SU11274是一种Met酪氨酸激酶抑制剂。

Targets

Target	Value
Met	IC50: 0.01μM
Flk1	IC50: 1.25μM
RON	IC50: 4.0μM
FGFR1	IC50: 8.5μM
CDK2	IC50: >10μM
PDGFRβ	IC50: >20μM
EGFR	IC50: >100μM

Solubility *

In vitro (25°C)	DMSO	83 mg/mL (146.1 mM)
	Water	Insoluble
	Ethanol	2 mg/mL
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.6 mL	88.01 mL	176.03 mL
0.5 mM	3.52 mL	17.6 mL	35.21 mL
1 mM	1.76 mL	8.8 mL	17.6 mL
5 mM	0.35 mL	1.76 mL	3.52 mL

*The above data is based on the productmolecular weight 568.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.