Tandutinib (MLN518)

Catalog No. A10887

Tandutinib (MLN518)是一种有效的FLT3抑制剂，c-KIT和PDGF受体酪氨酸激酶的自磷酸化，从而抑制细胞增殖并诱导细胞凋亡。

Technical details

Catalog Num	A10887
M. Wt	562.7
Formula	C31H42N6O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	387867-13-2
Synonyms	MLN-518, CT53518
SMILES	CC(C)OC1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCCC5

Biological Activity

Tandutinib (MLN518)是一种有效的FLT3抑制剂，c-KIT和PDGF受体酪氨酸激酶的自磷酸化，从而抑制细胞增殖并诱导细胞凋亡。

Targets

Target	Value
c-Kit	IC50: 0.17μM
PDGFRβ	IC50: 0.20μM
FLT3	IC50: 0.22μM
CSF-1R	IC50: 3.43μM
Src	IC50: 30μM
Abl	IC50: >30μM
PKC	IC50: >30μM
PKA	IC50: >30μM
MEK1	IC50: >30μM
MKK4	IC50: >30μM
MKK6	IC50: >30μM
ERK2	IC50: >30μM
p38	IC50: >30μM
KDR	IC50: >30μM
EGFR	IC50: >30μM
FGFR	IC50: >30μM
Insulin Receptor	IC50: >30μM

Solubility *

In vitro (25°C)	DMSO	5 mg/mL (8.88 mM)
	Water	Insoluble
	Ethanol	6 mg/mL (10.66 mM)
In vivo	0.5% methylcellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.77 mL	88.86 mL	177.71 mL
0.5 mM	3.55 mL	17.77 mL	35.54 mL
1 mM	1.78 mL	8.89 mL	17.77 mL
5 mM	0.36 mL	1.78 mL	3.55 mL

*The above data is based on the productmolecular weight 562.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.