Taxifolin

Catalog No. A10893

Taxifolin以很大的结合能值结合在VEGFR-2激酶的ATP结合位点上，并起I型竞争性抑制剂的作用。

Product Citations

Keji Yu, .et al. A role for ascorbate conjugates of (+)-catechin in proanthocyanidin polymerization, Nat Commun, 2022, Jun 14;13(1):3425 PMID: 35701431
Shinji Kondo, .et al. Antidiabetic Effect of Taxifolin in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Hyperglycemia and Hyperuricemia, Curr Issues Mol Biol, 2021, Sep 26;43(3):1293-1306 PMID: 34698101
Shin-ichi Adachi, .et al. Anti-hyperuricemic effect of taxifolin in cultured hepatocytes and model mice, Cytotechnology, 2017, Apr; 69(2): 329-336 PMID: 28101741

Technical details

Catalog Num	A10893
M. Wt	304.3
Formula	C15H12O7
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	480-18-2
Synonyms	Dihydroquercetin, Taxifoliol, Distylin, Catechin hydrate, (+)-Taxifolin, trans-Dihydroquercetin, (+)-Dihydroquercetin
SMILES	C1=CC(=C(C=C1[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

Biological Activity

Taxifolin以很大的结合能值结合在VEGFR-2激酶的ATP结合位点上，并起I型竞争性抑制剂的作用。

Targets

Solubility *

In vitro	DMSO	56 mg/mL (184.05 mM)
	Water	Insoluble
	Ethanol	56 mg/mL (184.05 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.86 mL	164.31 mL	328.62 mL
0.5 mM	6.57 mL	32.86 mL	65.72 mL
1 mM	3.29 mL	16.43 mL	32.86 mL
5 mM	0.66 mL	3.29 mL	6.57 mL

*The above data is based on the productmolecular weight 304.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.