Pexmetinib (ARRY-614)

Catalog No. A10895

Pexmetinib (ARRY-614)是通过双重抑制p38促分裂原活化蛋白激酶（MAPK）和Tie2/Tek受体酪氨酸激酶，其在HEK-293细胞中的IC50分别为4 nM/18 nM。Pexmetinib是一种有效的细胞因子合成抑制剂。

Technical details

Catalog Num	A10895
M. Wt	556.63
Formula	C31H33FN6O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	945614-12-0
Synonyms	ARRY614, ARRY 614
SMILES	O=C(NCC1=CC(F)=CC=C1OC2=CC3=C(N(CCO)N=C3)C=C2)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5

Biological Activity

Targets

p38 MAPK	Tie-2

Solubility *

In vitro	DMSO	96 mg/mL (172.46 mM)
	Water	Insoluble
	Ethanol	96 mg/mL (172.46 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.97 mL	89.83 mL	179.65 mL
0.5 mM	3.59 mL	17.97 mL	35.93 mL
1 mM	1.8 mL	8.98 mL	17.97 mL
5 mM	0.36 mL	1.8 mL	3.59 mL

*The above data is based on the productmolecular weight 556.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.