Telatinib (BAY 57-9352)
Catalog No. A10903
Telatinib (BAY 57-9352)是一种口服的血管内皮生长因子受体2和3(VEGFR2/3)和血小板衍生的生长因子受体β酪氨酸激酶的小分子抑制剂,IC50分别为6 nM/4 nM,1 nM和15 nM。
Catalog Num | A10903 |
---|---|
M. Wt | 409.8 |
Formula | C20H16ClN5O3 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 332012-40-5 |
Synonyms | BAY57-9352 |
SMILES | CNC(=O)C1=NC=CC(=C1)COC2=NN=C(C3=C2OC=C3)NC4=CC=C(C=C4)Cl |
Telatinib (BAY 57-9352)是一种口服的血管内皮生长因子受体2和3(VEGFR2/3)和血小板衍生的生长因子受体β酪氨酸激酶的小分子抑制剂,IC50分别为6 nM/4 nM,1 nM和15 nM。
Targets
c-Kit | VEGFR3 | VEGFR2 | PDGFRα | |
1 nM | 4 nM | 6 nM | 15 nM |
In vitro | DMSO | 71 mg/mL (173.24 mM) | |
Water | Insoluble | ||
Ethanol | 1 mg/mL (2.44 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 24.4 mL | 122.01 mL | 244.02 mL |
0.5 mM | 4.88 mL | 24.4 mL | 48.8 mL |
1 mM | 2.44 mL | 12.2 mL | 24.4 mL |
5 mM | 0.49 mL | 2.44 mL | 4.88 mL |
*The above data is based on the productmolecular weight 409.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.