Temsirolimus (Torisel)

Catalog No. A10906

Temsirolimus (Torisel)是mTOR的特异性抑制剂，会干扰调节肿瘤细胞增殖，生长和存活的蛋白质的合成。

Technical details

Catalog Num	A10906
M. Wt	1030.3
Formula	C56H87NO16
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	162635-04-3
Synonyms	CCI-779
SMILES	C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C\C=C\[C@H](C[C@H](C(=O)[C@H]([C@H](/C(=C\[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OC(=O)C(C)(CO)CO)C)/C)O)OC)C)C)/C)OC

Biological Activity

Temsirolimus (Torisel)是mTOR的特异性抑制剂，会干扰调节肿瘤细胞增殖，生长和存活的蛋白质的合成。

Targets

mTOR (Cell-free assay)
1.76 μM

Solubility *

In vitro (25°C)	DMSO	60 mg/mL (58.24 mM)
	Water	Insoluble
	Ethanol	67 mg/mL (65.03 mM)
In vivo	2% DMSO+30% PEG 300 +2% Tween 80+ddH2O	6 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	9.71 mL	48.53 mL	97.06 mL
0.5 mM	1.94 mL	9.71 mL	19.41 mL
1 mM	0.97 mL	4.85 mL	9.71 mL
5 mM	0.19 mL	0.97 mL	1.94 mL

*The above data is based on the productmolecular weight 1030.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.