Tenofovir Disoproxil Fumarate
Catalog No. A10909
Tenofovir Disoproxil Fumarate属于一类抗逆转录病毒药物,其通过与天然底物脱氧腺苷5’-三磷酸盐竞争以及整合到DNA后终止DNA链抑制HIV reverse transcriptase活性。
- Kazumoto Murata, .et al. Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection, Gut, 2018, Feb; 67(2): 362-371 PMID: 27789659
Catalog Num | A10909 |
---|---|
M. Wt | 635.51 |
Formula | C19H30N5O10P.C4H4O4 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 202138-50-9 |
Synonyms | Viread |
SMILES | C[C@H](CN1C=NC2=C1N=CN=C2N)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C.C(=C/C(=O)O)\C(=O)O |
Tenofovir Disoproxil Fumarate属于一类抗逆转录病毒药物,其通过与天然底物脱氧腺苷5’-三磷酸盐竞争以及整合到DNA后终止DNA链抑制HIV reverse transcriptase活性。
Targets
HIV reverse transcriptase (Cell-free assay) | ||||
In vitro | DMSO | 88 mg/mL (138.47 mM) | |
Water | Insoluble | ||
Ethanol | 39 mg/mL (61.36 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 15.74 mL | 78.68 mL | 157.35 mL |
0.5 mM | 3.15 mL | 15.74 mL | 31.47 mL |
1 mM | 1.57 mL | 7.87 mL | 15.74 mL |
5 mM | 0.31 mL | 1.57 mL | 3.15 mL |
*The above data is based on the productmolecular weight 635.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.