Tenofovir Disoproxil Fumarate

Catalog No. A10909

Tenofovir Disoproxil Fumarate属于一类抗逆转录病毒药物,其通过与天然底物脱氧腺苷5’-三磷酸盐竞争以及整合到DNA后终止DNA链抑制HIV reverse transcriptase活性。
  • Kazumoto Murata, .et al. Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection, Gut, 2018, Feb; 67(2): 362-371 PMID: 27789659
Catalog Num A10909
M. Wt 635.51
Formula C19H30N5O10P.C4H4O4
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 202138-50-9
Synonyms Viread
SMILES C[C@H](CN1C=NC2=C1N=CN=C2N)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C.C(=C/C(=O)O)\C(=O)O
Tenofovir Disoproxil Fumarate属于一类抗逆转录病毒药物,其通过与天然底物脱氧腺苷5’-三磷酸盐竞争以及整合到DNA后终止DNA链抑制HIV reverse transcriptase活性。
Targets
HIV reverse transcriptase (Cell-free assay)
In vitro DMSO 88 mg/mL (138.47 mM)
Water Insoluble
Ethanol 39 mg/mL (61.36 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.74 mL 78.68 mL 157.35 mL
0.5 mM 3.15 mL 15.74 mL 31.47 mL
1 mM 1.57 mL 7.87 mL 15.74 mL
5 mM 0.31 mL 1.57 mL 3.15 mL

*The above data is based on the productmolecular weight 635.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.