TG100-115

Catalog No. A10922

TG100-115是一种PI3Kγ/δ抑制剂（IC50值分别为83和235 nM）。

Technical details

Catalog Num	A10922
M. Wt	346.3
Formula	C18H14N6O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	677297-51-7
Synonyms	TG100115
SMILES	C1=CC(=CC(=C1)O)C2=NC3=C(N=C2C4=CC(=CC=C4)O)N=C(N=C3N)N

Biological Activity

TG100-115是一种PI3Kγ/δ抑制剂（IC50值分别为83和235 nM）。

Targets

PI3Kγ	PI3Kδ	PI3Kβ	PI3Kα
83 nM	235 nM	1.2 μM	1.3 μM

Solubility *

In vitro (25°C)	DMSO	8 mg/mL (23.09 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+ddH2O	0.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.88 mL	144.38 mL	288.77 mL
0.5 mM	5.78 mL	28.88 mL	57.75 mL
1 mM	2.89 mL	14.44 mL	28.88 mL
5 mM	0.58 mL	2.89 mL	5.78 mL

*The above data is based on the productmolecular weight 346.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.