Tipifarnib (Zarnestra)

Catalog No. A10935

Tipifarnib (Zarnestra)是一种法尼基转移酶抑制剂,可在激酶途径变得过度活跃之前的翻译后修饰步骤中抑制Ras激酶。
  • Xiaoming Liu, .et al. Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy, J Immunother Cancer, 2022, Apr;10(4):e004399 PMID: 35483745
Catalog Num A10935
M. Wt 489.4
Formula C27H22Cl2N4O
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 192185-72-1
Synonyms IND 58359, R115777
SMILES CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N
Tipifarnib (Zarnestra)是一种法尼基转移酶抑制剂,可在激酶途径变得过度活跃之前的翻译后修饰步骤中抑制Ras激酶。
Targets
FTase
0.6 nM
In vitro (25°C) DMSO 14 mg/mL (28.6 mM)
Water Insoluble
Ethanol Insoluble
In vivo 15% Captisol+citrate vehicle 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.43 mL 102.17 mL 204.33 mL
0.5 mM 4.09 mL 20.43 mL 40.87 mL
1 mM 2.04 mL 10.22 mL 20.43 mL
5 mM 0.41 mL 2.04 mL 4.09 mL

*The above data is based on the productmolecular weight 489.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.