TW-37

Catalog No. A10955

TW-37是Bcl-2的小分子抑制剂，可抑制胰腺癌细胞的生长，并通过一种涉及Notch-1和Jagged-1失活的新途径介导的胰腺癌细胞凋亡。

Technical details

Catalog Num	A10955
M. Wt	573.7
Formula	C33H35NO6S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	877877-35-5
Synonyms	TW37
SMILES	CC(C)C1=CC=CC=C1CC2=C(C(=C(C(=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)C4=CC=CC=C4C(C)(C)C)O)O)O

Biological Activity

TW-37是Bcl-2的小分子抑制剂，可抑制胰腺癌细胞的生长，并通过一种涉及Notch-1和Jagged-1失活的新途径介导的胰腺癌细胞凋亡。

Targets

Mcl-1 (Cell-free assay)	Bcl-2 (Cell-free assay)	Bcl-xL (Cell-free assay)
0.26 μM(Ki)	0.29 μM(Ki)	1.11 μM(Ki)

Solubility *

In vitro (25°C)	DMSO	110 mg/mL (191.73 mM)
	Water	Insoluble
	Ethanol	4 mg/mL (6.97 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.43 mL	87.15 mL	174.31 mL
0.5 mM	3.49 mL	17.43 mL	34.86 mL
1 mM	1.74 mL	8.72 mL	17.43 mL
5 mM	0.35 mL	1.74 mL	3.49 mL

*The above data is based on the productmolecular weight 573.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.