U0126-EtOH

Catalog No. A10957

U0126-EtOH是MEK1和MEK2的抑制剂，IC50分别为72 nM和58 nM。

Product Citations

Hanna Galganska, .et al. Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors, Cell Mol Life Sci, 2021, Dec;78(24):8229-8242 PMID: 34741187
Paul Mark Medina, .et al. Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains, Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682
Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
Choe YJ, .et al. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53., Int J Oncol., 2014, 44(3):761-8. PMID: 24366007

Technical details

Catalog Num	A10957
M. Wt	426.6
Formula	C18H16N6S2.C2H6O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1173097-76-1
Synonyms
SMILES	CCO.C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N

Biological Activity

U0126-EtOH是MEK1和MEK2的抑制剂，IC50分别为72 nM和58 nM。

Targets

Target	Value
MEK2	IC50: 0.06μM
MEK1	IC50: 0.07μM
PKC	IC50: >10μM
CDK2	IC50: >10μM
CDK4	IC50: >10μM
MKK6/p38MAPK	IC50: 20μM
MKK3/p38MAPK	IC50: 38μM
ERK1/2	IC50: >50μM
JNK	IC50: >100μM
MKK4	IC50: >100μM
Abl	IC50: >100μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 77 mg/mL (180.51 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+40%PEG300+5%Tween 80+50%H2O	4.03 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.44 mL	117.21 mL	234.41 mL
0.5 mM	4.69 mL	23.44 mL	46.88 mL
1 mM	2.34 mL	11.72 mL	23.44 mL
5 mM	0.47 mL	2.34 mL	4.69 mL

*The above data is based on the productmolecular weight 426.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.