Vatalanib (PTK787) 2HCl

Catalog No. A10967

Vatalanib (PTK787) 2HCl是一种小分子蛋白激酶抑制剂，可抑制抑制所有已知VEGF受体以及血小板衍生的生长因子受体β和c-kit的血管生成，但对VEGFR-2的选择性最高。

Technical details

Catalog Num	A10967
M. Wt	419.7
Formula	C20H17Cl3N4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	212141-51-0
Synonyms	Vatalanib,PTK787,PTK/ZK
SMILES	C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl

Biological Activity

Targets

Target	Value
VEGFR2/KDR	IC50: 37nM
VEGFR1/FLT1	IC50: 77nM
VEGFR2/Flk1	IC50: 270nM
PDGFRβ	IC50: 580nM
VEGFR3/FLT4	IC50: 660nM
c-Kit	IC50: 730nM
c-Fms	IC50: 1.4μM

Solubility *

In vitro	DMSO	77 mg/mL (183.45 mM)
	Water	9 mg/mL (21.44 mM)
	Ethanol	5 mg/mL (11.91 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.83 mL	119.13 mL	238.27 mL
0.5 mM	4.77 mL	23.83 mL	47.65 mL
1 mM	2.38 mL	11.91 mL	23.83 mL
5 mM	0.48 mL	2.38 mL	4.77 mL

*The above data is based on the productmolecular weight 419.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.