Vinorelbine (Navelbine)

Catalog No. A10976

Vinorelbine (Navelbine)是第一个5?NOR半合成长春花生物碱。它是通过半合成从玫瑰色长春花，长春花中提取的生物碱中获得的。

Product Citations

Rotem Ben-Hamo, .et al. Predicting and affecting response to cancer therapy based on pathway-level biomarkers, Nat Commun, 2020, 11: 3296
Roma Kaul, .et al. Eribulin rapidly inhibits TGF-β-induced Snail expression and can induce Slug expression in a Smad4-dependent manner, Br J Cancer, 2019, 121, pages611-621 PMID: 31481735
Nicholas F. Dybdal-Hargreaves, .et al. Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130Cas/Src inhibition by eribulin, Oncotarget, 2018, Jan 19; 9(5): 5545-5561 PMID: 29464017
APRIL L. RISINGER, .et al. Breast Cancer Cell Lines Exhibit Differential Sensitivities to Microtubule-targeting Drugs Independent of Doubling Time, Anticancer Res, 2015, Nov; 35(11): 5845-5850. PMID: 26504006

Technical details

Catalog Num	A10976
M. Wt	778.9
Formula	C45H54N4O8
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	71486-22-1
Synonyms
SMILES	CCC1=C[C@H]2C[C@@](C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC

Biological Activity

Vinorelbine (Navelbine)是第一个5?NOR半合成长春花生物碱。它是通过半合成从玫瑰色长春花，长春花中提取的生物碱中获得的。

Solubility *

In vitro	DMSO	99 mg/mL (91.73 mM)
	Water	Warmed: 99 mg/mL (91.73 mM)
	Ethanol	Warmed: 99 mg/mL (91.73 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	12.84 mL	64.19 mL	128.39 mL
0.5 mM	2.57 mL	12.84 mL	25.68 mL
1 mM	1.28 mL	6.42 mL	12.84 mL
5 mM	0.26 mL	1.28 mL	2.57 mL

*The above data is based on the productmolecular weight 778.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.