VX-745

Catalog No. A10983

VX-745是一种有效的，选择性p38α抑制剂，IC50为10 nM，比作用于p38β选择性高22倍，对p38γ没有抑制作用。

Technical details

Catalog Num	A10983
M. Wt	436.3
Formula	C19H9Cl2F2N3OS
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	209410-46-8
Synonyms	VX745
SMILES	C1=CC(=C(C(=C1)Cl)C2=C3C=CC(=NN3C=NC2=O)SC4=C(C=C(C=C4)F)F)Cl

Biological Activity

VX-745是一种有效的，选择性p38α抑制剂，IC50为10 nM，比作用于p38β选择性高22倍，对p38γ没有抑制作用。

Targets

p38α	p38β
10 nM	220 nM

Solubility *

In vitro (25°C)	DMSO	15 mg/mL (34.38 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.92 mL	114.6 mL	229.2 mL
0.5 mM	4.58 mL	22.92 mL	45.84 mL
1 mM	2.29 mL	11.46 mL	22.92 mL
5 mM	0.46 mL	2.29 mL	4.58 mL

*The above data is based on the productmolecular weight 436.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.