WYE-354

Catalog No. A10989

WYE-354是一种有效的mTOR细胞渗透抑制剂（IC50 = 4.3 nM），可阻断通过mTOR复合体1（mTORC1）和mTORC2的信号传导。它是PI3Kα（IC50 = 1026 nM）和其他激酶的弱得多的抑制剂。

Product Citations

H Weber ,etc. Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice. Oncotarget, 2015, 6(31), 31877.

Technical details

Catalog Num	A10989
M. Wt	495.5
Formula	C24H29N7O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1062169-56-5
Synonyms	WYE354
SMILES	COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5

Biological Activity

Targets

Target	Value
mTOR	IC50: 5nM
PI3Kα	IC50: 1.89μM
PI3Kγ	IC50: 7.37μM
GCK	IC50: >50μM
Hck	IC50: >50μM
IKKα	IC50: >50μM
Lyn	IC50: >50μM
Met	IC50: >50μM
MK2	IC50: >50μM
p38α	IC50: >50μM
PDGFRα	IC50: >50μM
PKA	IC50: >50μM
PKBα	IC50: >50μM
PKCα	IC50: >50μM
PKCβ	IC50: >50μM
ROCK1	IC50: >50μM
RSK1	IC50: >50μM
Src	IC50: >50μM
VEGFR2	IC50: >50μM
Abl1	IC50: >50μM
AuroraB	IC50: >50μM
CDK1/CyclinB	IC50: >50μM
CDK2/CyclinA	IC50: >50μM
Chk1	IC50: >50μM
ERK2	IC50: >50μM
Fyn	IC50: >50μM

Solubility *

In vitro (25°C)	DMSO	95 mg/mL (191.71 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.18 mL	100.91 mL	201.82 mL
0.5 mM	4.04 mL	20.18 mL	40.36 mL
1 mM	2.02 mL	10.09 mL	20.18 mL
5 mM	0.4 mL	2.02 mL	4.04 mL

*The above data is based on the productmolecular weight 495.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.