WZ3146
Catalog No. A10990
WZ3146是EGFR受体激酶突变体的抑制剂,该突变体在活性位点网守残基(T790M)中带有突变,并且对野生型EGFR激酶的效力要低得多。
Catalog Num | A10990 |
---|---|
M. Wt | 465.0 |
Formula | C24H25ClN6O2 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1214265-56-1 |
Synonyms | WZ-3146 |
SMILES | CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl |
WZ3146是EGFR受体激酶突变体的抑制剂,该突变体在活性位点网守残基(T790M)中带有突变,并且对野生型EGFR激酶的效力要低得多。
Targets
EGFR (L858R) | EGFR (E746_A750) | EGFR (L858R/T790M) | EGFR (E746_A750/T790M) | |
2 nM | 2 nM | 5 nM | 14 nM |
In vitro | DMSO | 83 mg/mL (178.51 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 21.51 mL | 107.53 mL | 215.05 mL |
0.5 mM | 4.3 mL | 21.51 mL | 43.01 mL |
1 mM | 2.15 mL | 10.75 mL | 21.51 mL |
5 mM | 0.43 mL | 2.15 mL | 4.3 mL |
*The above data is based on the productmolecular weight 465.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.