WZ3146

Catalog No. A10990

WZ3146是EGFR受体激酶突变体的抑制剂,该突变体在活性位点网守残基(T790M)中带有突变,并且对野生型EGFR激酶的效力要低得多。
Catalog Num A10990
M. Wt 465.0
Formula C24H25ClN6O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1214265-56-1
Synonyms WZ-3146
SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl
WZ3146是EGFR受体激酶突变体的抑制剂,该突变体在活性位点网守残基(T790M)中带有突变,并且对野生型EGFR激酶的效力要低得多。
Targets
EGFR (L858R) EGFR (E746_A750) EGFR (L858R/T790M) EGFR (E746_A750/T790M)
2 nM2 nM5 nM14 nM
In vitro DMSO 83 mg/mL (178.51 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.51 mL 107.53 mL 215.05 mL
0.5 mM 4.3 mL 21.51 mL 43.01 mL
1 mM 2.15 mL 10.75 mL 21.51 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 465.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.