XAV 939

Catalog No. A10994

XAV 939是TNKS抑制剂（TNKS1和TNKS2的IC50值分别为0.011和0.004μM）。

Product Citations

Shizu Aikawa, .et al. Autotaxin-lysophosphatidic acid-LPA 3 signaling at the embryo-epithelial boundary controls decidualization pathways, EMBO J, 2017, Jul 14; 36(14): 2146-2160 PMID: 28588064
Mikaël M. Martino, .et al. Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration, Nat Commun, 2016, 7: 11051 PMID: 27001940

Technical details

Catalog Num	A10994
M. Wt	312.3
Formula	C14H11F3N2OS
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	284028-89-3
Synonyms	XAV939, XAV-939
SMILES	C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F

Biological Activity

XAV 939是TNKS抑制剂（TNKS1和TNKS2的IC50值分别为0.011和0.004μM）。

Targets

TNKS2 (Cell-free assay)	TNKS1 (Cell-free assay)
4 nM	11 nM

Solubility *

In vitro (25°C)	DMSO	12 mg/mL (38.42 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+corn oil	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.02 mL	160.1 mL	320.2 mL
0.5 mM	6.4 mL	32.02 mL	64.04 mL
1 mM	3.2 mL	16.01 mL	32.02 mL
5 mM	0.64 mL	3.2 mL	6.4 mL

*The above data is based on the productmolecular weight 312.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.