XL765

Catalog No. A10997

XL765是PI3K/mTOR双激酶抑制剂，与单独抑制PI3K激酶或mTOR激酶的药物相比，它的效力更高。

Technical details

Catalog Num	A10997
M. Wt	599.7
Formula	C31H29N5O6S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1349796-36-6
Synonyms	XL-765
SMILES	CC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4N=C3NC5=CC(=CC(=C5)OC)OC)OC

Biological Activity

XL765是PI3K/mTOR双激酶抑制剂，与单独抑制PI3K激酶或mTOR激酶的药物相比，它的效力更高。

Targets

Target	Value
PI3Kγ	IC50: 9nM
PI3Kα	IC50: 39nM
PI3Kδ	IC50: 43nM
PI3Kβ	IC50: 113nM
DNA-PK	IC50: 150nM
mTOR	IC50: 157nM

Solubility *

In vitro (25°C)	DMSO	10 mg/mL (16.68 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.68 mL	83.38 mL	166.75 mL
0.5 mM	3.34 mL	16.68 mL	33.35 mL
1 mM	1.67 mL	8.34 mL	16.68 mL
5 mM	0.33 mL	1.67 mL	3.34 mL

*The above data is based on the productmolecular weight 599.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.