Y-27632 2HCl

Catalog No. A11001

Y-27632是一种Rho相关的线圈激酶（ROCK）抑制剂，可提高人类胚胎干细胞（hESCs）的克隆效率。比对其他激酶包括PKC，cAMP依赖性蛋白激酶，MLCK和PAK的作用强200多倍。

Product Citations

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Technical details

Catalog Num	A11001
M. Wt	320.3
Formula	C14H21N3O.2HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	146986-50-7, 129830-38-2
Synonyms
SMILES	C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl

Biological Activity

Targets

ROCK1 (p160ROCK) (Cell-free assay)	ROCK2 (Cell-free assay)
140 nM(Ki)	300 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	Warmed: 61 mg/mL (190.46 mM)
	Water	13 mg/mL (40.59 mM)
	Ethanol	Insoluble
In vivo	saline	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.22 mL	156.1 mL	312.21 mL
0.5 mM	6.24 mL	31.22 mL	62.44 mL
1 mM	3.12 mL	15.61 mL	31.22 mL
5 mM	0.62 mL	3.12 mL	6.24 mL

*The above data is based on the productmolecular weight 320.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.