ZM-447439

Catalog No. A11009

ZM 447439是Aurora A和Aurora B的选择性和ATP竞争性抑制剂，IC50分别为110 nM和130 nM。它对Aurora A/B的选择性是MEK1，Src，Lck的8倍以上，对CDK1/2/4，Plk1，Chk1等的影响很小。

Technical details

Catalog Num	A11009
M. Wt	513.6
Formula	C29H31N5O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	331771-20-1
Synonyms	ZM447439
SMILES	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5

Biological Activity

Targets

Target	Value
AuroraA	IC50: 110nM
AuroraB	IC50: 130nM
LCK	IC50: 880nM
Src	IC50: 1.03μM
MEK1	IC50: 1.79μM
CDK1	IC50: >10μM
CDK2	IC50: >10μM
CDK4	IC50: >10μM
PLK1	IC50: >10μM
Chk1	IC50: >10μM
IKK1	IC50: >10μM
IKK2	IC50: >10μM
cFLT2	IC50: >10μM
KDR2	IC50: >10μM
ZAP70	IC50: >10μM
FAK	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	90 mg/mL (175.23 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.47 mL	97.35 mL	194.7 mL
0.5 mM	3.89 mL	19.47 mL	38.94 mL
1 mM	1.95 mL	9.74 mL	19.47 mL
5 mM	0.39 mL	1.95 mL	3.89 mL

*The above data is based on the productmolecular weight 513.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.