ZSTK474

Catalog No. A11014

ZSTK474是I类磷脂酰肌醇3激酶同工型的ATP竞争性抑制剂。

Product Citations

Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844

Technical details

Catalog Num	A11014
M. Wt	417.4
Formula	C19H21F2N7O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	475110-96-4
Synonyms
SMILES	C1COCCN1C2=NC(=NC(=N2)N3C4=CC=CC=C4N=C3C(F)F)N5CCOCC5

Biological Activity

ZSTK474是I类磷脂酰肌醇3激酶同工型的ATP竞争性抑制剂。

Targets

PI3Kδ (Cell-free assay)	PI3Kα (Cell-free assay)	PI3K (Cell-free assay)	PI3Kβ (Cell-free assay)	PI3Kγ (Cell-free assay)
4.6 nM	16 nM	37 nM	44 nM	49 nM

Solubility *

In vitro (25°C)	DMSO	20 mg/mL (47.91 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% hydroxyethyl cellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.96 mL	119.79 mL	239.58 mL
0.5 mM	4.79 mL	23.96 mL	47.92 mL
1 mM	2.4 mL	11.98 mL	23.96 mL
5 mM	0.48 mL	2.4 mL	4.79 mL

*The above data is based on the productmolecular weight 417.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.