LY2157299

Catalog No. A11017

LY2157299是一种口服活性转化生长因子β受体（TGF-βR）激酶抑制剂。

Product Citations

Satoshi Endo, .et al. Flavonol glycosides of Rosa multiflora regulates intestinal barrier function through inhibiting claudin expression in differentiated Caco-2 cells, Nutr Res, 2019, 4 November
Oguri G, .et al. Effects of methylglyoxal on human cardiac fibroblast: roles of transient receptor potential ankyrin 1 (TRPA1) channels., Am J Physiol Heart Circ Physiol., 2014, 307(9):H1339-52 PMID: 25172898

Technical details

Catalog Num	A11017
M. Wt	369.4
Formula	C22H19N5O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	700874-72-2
Synonyms	LY-2157299
SMILES	CC1=CC=CC(=N1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N

Biological Activity

LY2157299是一种口服活性转化生长因子β受体（TGF-βR）激酶抑制剂。

Targets

TβRI (Cell-free assay)
56 nM

Solubility *

In vitro (25°C)	DMSO	66 mg/mL (178.65 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1%CMC-Na	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.07 mL	135.35 mL	270.71 mL
0.5 mM	5.41 mL	27.07 mL	54.14 mL
1 mM	2.71 mL	13.54 mL	27.07 mL
5 mM	0.54 mL	2.71 mL	5.41 mL

*The above data is based on the productmolecular weight 369.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.