NVP-AEW541

Catalog No. A11021

NVP-AEW541是一种选择性的IGF-1R激酶抑制剂，可抑制IGF-1R的自磷酸化活性（IC50 = 0.086 uM）并阻止IGF-1介导的MCF-7细胞存活和增殖（IC50分别为0.16和1.64 uM）。

Product Citations

Tsushima H, .et al. Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis, Autoimmunity, 2017, Aug;50(5):329-335 PMID: 28682648

Technical details

Catalog Num	A11021
M. Wt	439.6
Formula	C27H29N5O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	475489-16-8
Synonyms	AEW541
SMILES	C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6

Biological Activity

NVP-AEW541是一种选择性的IGF-1R激酶抑制剂，可抑制IGF-1R的自磷酸化活性（IC50 = 0.086 uM）并阻止IGF-1介导的MCF-7细胞存活和增殖（IC50分别为0.16和1.64 uM）。

Solubility *

In vitro (25°C)	DMSO	77 mg/mL (175.18 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.75 mL	113.74 mL	227.48 mL
0.5 mM	4.55 mL	22.75 mL	45.5 mL
1 mM	2.27 mL	11.37 mL	22.75 mL
5 mM	0.45 mL	2.27 mL	4.55 mL

*The above data is based on the productmolecular weight 439.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.