AG-1478 (Tyrphostin AG-1478)

Catalog No. A11022

AG-1478 (Tyrphostin AG-1478)是EGFR激酶的抑制剂，IC50值为3 nM。

Product Citations

Khattab M, .et al. Conformational Plasticity in Tyrosine Kinase Inhibitor-Kinase Interactions Revealed with Fluorescence Spectroscopy and Theoretical Calculations, J Phys Chem B, 2018, May 3;122(17):4667-4679 PMID: 29629773
Muhammad Khattab, .et al. A pH-induced conformational switch in a tyrosine kinase inhibitor identified by electronic spectroscopy and quantum chemical calculations, Sci Rep, 2017, 7: 16271 PMID: 29176733

Technical details

Catalog Num	A11022
M. Wt	315.8
Formula	C16H14ClN3O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	153436-53-4
Synonyms	AG1478, AG 1478
SMILES	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC

Biological Activity

AG-1478 (Tyrphostin AG-1478)是EGFR激酶的抑制剂，IC50值为3 nM。

Targets

EGFR (Cell-free assay)	HER2 (Cell-free assay)	PDGFR (Cell-free assay)
3 nM	>100 μM	>100 μM

Solubility *

In vitro (25°C)	DMSO	25 mg/mL (79.17 mM)
	Water	Insoluble
	Ethanol	13 mg/mL (41.17 mM)
In vivo	15% Captisol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.67 mL	158.33 mL	316.66 mL
0.5 mM	6.33 mL	31.67 mL	63.33 mL
1 mM	3.17 mL	15.83 mL	31.67 mL
5 mM	0.63 mL	3.17 mL	6.33 mL

*The above data is based on the productmolecular weight 315.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.