GDC-0980 (Apitolisib, RG7422)

Catalog No. A11023

GDC-0980 (Apitolisib,RG7422)是一种有效的，I型PI3激酶和mTOR激酶抑制剂（TORC1/2），对于p110α，β，δ和γ的体外IC50为5、27、7和14 nM。

Product Citations

Kasun Wanigasooriya, .et al. Patient Derived Organoids Confirm That PI3K/AKT Signalling Is an Escape Pathway for Radioresistance and a Target for Therapy in Rectal Cancer, Front Oncol, 2022, Jul 4;12:920444 PMID: 35860583

Technical details

Catalog Num	A11023
M. Wt	498.6
Formula	C23H30N8O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1032754-93-0
Synonyms	GDC0980
SMILES	CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)[C@H](C)O

Biological Activity

GDC-0980 (Apitolisib,RG7422)是一种有效的，I型PI3激酶和mTOR激酶抑制剂（TORC1/2），对于p110α，β，δ和γ的体外IC50为5、27、7和14 nM。

Targets

p110α (Cell-free assay)	p110δ (Cell-free assay)	p110γ (Cell-free assay)	mTOR (Cell-free assay)	p110β (Cell-free assay)
5 nM	7 nM	14 nM	17 nM(Ki app)	27 nM

Solubility *

In vitro (25°C)	DMSO	20 mg/mL (40.11 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% methylcellulose+0.2% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.06 mL	100.28 mL	200.56 mL
0.5 mM	4.01 mL	20.06 mL	40.11 mL
1 mM	2.01 mL	10.03 mL	20.06 mL
5 mM	0.4 mL	2.01 mL	4.01 mL

*The above data is based on the productmolecular weight 498.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.