PF-04691502

Catalog No. A11024

PF-04691502是PI3K/mTOR激酶抑制剂，也是在PI3K/mTOR信号传导途径中靶向磷脂酰肌醇3激酶（PI3K）和雷帕霉素（mTOR）哺乳动物靶标的药物。

Technical details

Catalog Num	A11024
M. Wt	425.5
Formula	C22H27N5O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1013101-36-4
Synonyms	PF04691502
SMILES	CC1=C2C=C(C(=O)N(C2=NC(=N1)N)C3CCC(CC3)OCCO)C4=CN=C(C=C4)OC

Biological Activity

PF-04691502是PI3K/mTOR激酶抑制剂，也是在PI3K/mTOR信号传导途径中靶向磷脂酰肌醇3激酶（PI3K）和雷帕霉素（mTOR）哺乳动物靶标的药物。

Targets

Target	Value
PI3Kδ	ki: 1.6nM
PI3Kα	ki: 1.8nM
PI3Kγ	ki: 1.9nM
PI3Kβ	ki: 2.1nM
P-Akt(S473)	IC50: 3.8nM
P-Akt(T308)	IC50: 7.5nM
mTOR	ki: 16nM

Solubility *

In vitro	DMSO	13 mg/mL (30.55 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.5 mL	117.51 mL	235.02 mL
0.5 mM	4.7 mL	23.5 mL	47 mL
1 mM	2.35 mL	11.75 mL	23.5 mL
5 mM	0.47 mL	2.35 mL	4.7 mL

*The above data is based on the productmolecular weight 425.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.