GSK2126458 (Omipalisib)

Catalog No. A11035

GSK2126458 (Omipalisib)是一种高选择性的,有效的p110α/β/γ/δ和 mTORC1/2抑制剂,无细胞试验中Ki分别为0.019 nM/0.13 nM/0.024 nM/0.06 nM和0.18 nM/0.3 nM。
Catalog Num A11035
M. Wt 505.5
Formula C25H17F2N5O3S
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1086062-66-9
Synonyms GSK-2126458
SMILES COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F
GSK2126458 (Omipalisib)是一种高选择性的,有效的p110α/β/γ/δ和 mTORC1/2抑制剂,无细胞试验中Ki分别为0.019 nM/0.13 nM/0.024 nM/0.06 nM和0.18 nM/0.3 nM。
Targets
Target Value
p110αki: 0.019nM
p110δki: 0.024nM
p110γki: 0.06nM
p110βki: 0.13nM
mTORC1ki: 0.18nM
mTORC2ki: 0.3nM
In vitro (25°C) DMSO 96 mg/mL (189.91 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+40% PEG 300+2% Tween 80+ddH2O 3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.78 mL 98.91 mL 197.82 mL
0.5 mM 3.96 mL 19.78 mL 39.56 mL
1 mM 1.98 mL 9.89 mL 19.78 mL
5 mM 0.4 mL 1.98 mL 3.96 mL

*The above data is based on the productmolecular weight 505.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.