AR-42 (HDAC-42)

Catalog No. A11037

AR-42 (HDAC-42)是一种新型的HDAC抑制剂，通过下调本构激活的Kit表现出对恶性肥大细胞系的生物学活性。

Product Citations

Yong-Hui Liao, .et al. Histone deacetylase 2 is involved in μ-opioid receptor suppression in the spinal dorsal horn in a rat model of chronic pancreatitis pain, Mol Med Rep, 2018, Feb; 17(2): 2803-2810 PMID: 29257262

Technical details

Catalog Num	A11037
M. Wt	312.4
Formula	C18H20N2O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	935881-37-1
Synonyms	AR42, OSU-HDAC42
SMILES	CC(C)[C@@H](C1=CC=CC=C1)C(=O)NC2=CC=C(C=C2)C(=O)NO

Biological Activity

AR-42 (HDAC-42)是一种新型的HDAC抑制剂，通过下调本构激活的Kit表现出对恶性肥大细胞系的生物学活性。

Targets

HDAC
30 nM

Solubility *

In vitro (25°C)	DMSO	62 mg/mL (198.49 mM)
	Water	Insoluble
	Ethanol	62 mg/mL (198.49 mM)
In vivo	0.5% methylcellulose+0.2% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.01 mL	160.05 mL	320.1 mL
0.5 mM	6.4 mL	32.01 mL	64.02 mL
1 mM	3.2 mL	16.01 mL	32.01 mL
5 mM	0.64 mL	3.2 mL	6.4 mL

*The above data is based on the productmolecular weight 312.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.