WYE-125132 (WYE-132)

Catalog No. A11038

WYE-125132 (WYE-132)是一种高度有效的,ATP竞争性的mTOR抑制剂,IC50为0.19 nM;作用于mTOR比作用于PI3Ks或PI3K相关激酶hSMG1和ATR选择性高。
Catalog Num A11038
M. Wt 519.6
Formula C27H33N7O4
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1144068-46-1
Synonyms WYE125132, WYE-132, WYE132
SMILES CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7
WYE-125132 (WYE-132)是一种高度有效的,ATP竞争性的mTOR抑制剂,IC50为0.19 nM;作用于mTOR比作用于PI3Ks或PI3K相关激酶hSMG1和ATR选择性高。
Targets
mTOR
0.19 nM
In vitro (25°C) DMSO 95 mg/mL (182.83 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.25 mL 96.23 mL 192.46 mL
0.5 mM 3.85 mL 19.25 mL 38.49 mL
1 mM 1.92 mL 9.62 mL 19.25 mL
5 mM 0.38 mL 1.92 mL 3.85 mL

*The above data is based on the productmolecular weight 519.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.