TAK-733

Catalog No. A11040

TAK-733是一种有效的,选择性的MEK变构抑制剂,作用于MEK1,IC50为3.2 nM,抑制Abl1,AKT3,c-RAF,CamK1,CDK2及c-Met等活性。
Catalog Num A11040
M. Wt 504.2
Formula C17H15F2IN4O4
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1035555-63-5
Synonyms TAK733
SMILES CN1C2=C(C(=C(C1=O)F)NC3=C(C=C(C=C3)I)F)C(=O)N(C=N2)C[C@H](CO)O
TAK-733是一种有效的,选择性的MEK变构抑制剂,作用于MEK1,IC50为3.2 nM,抑制Abl1,AKT3,c-RAF,CamK1,CDK2及c-Met等活性。
Targets
MEK1
3.2 nM
In vitro DMSO 99 mg/mL (196.33 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.83 mL 99.17 mL 198.33 mL
0.5 mM 3.97 mL 19.83 mL 39.67 mL
1 mM 1.98 mL 9.92 mL 19.83 mL
5 mM 0.4 mL 1.98 mL 3.97 mL

*The above data is based on the productmolecular weight 504.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.