TAK-733
Catalog No. A11040
TAK-733是一种有效的,选择性的MEK变构抑制剂,作用于MEK1,IC50为3.2 nM,抑制Abl1,AKT3,c-RAF,CamK1,CDK2及c-Met等活性。
Catalog Num | A11040 |
---|---|
M. Wt | 504.2 |
Formula | C17H15F2IN4O4 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1035555-63-5 |
Synonyms | TAK733 |
SMILES | CN1C2=C(C(=C(C1=O)F)NC3=C(C=C(C=C3)I)F)C(=O)N(C=N2)C[C@H](CO)O |
TAK-733是一种有效的,选择性的MEK变构抑制剂,作用于MEK1,IC50为3.2 nM,抑制Abl1,AKT3,c-RAF,CamK1,CDK2及c-Met等活性。
Targets
MEK1 | ||||
3.2 nM |
In vitro | DMSO | 99 mg/mL (196.33 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 19.83 mL | 99.17 mL | 198.33 mL |
0.5 mM | 3.97 mL | 19.83 mL | 39.67 mL |
1 mM | 1.98 mL | 9.92 mL | 19.83 mL |
5 mM | 0.4 mL | 1.98 mL | 3.97 mL |
*The above data is based on the productmolecular weight 504.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.