Tubastatin A HCl

Catalog No. A11042

Tubastatin A HCl是一种有效的选择性HDAC6抑制剂，在无细胞试验中IC50为15 nM。它对除HDAC8（57倍）以外的所有其他同工酶（1000倍）具有选择性。

Product Citations

Isin Cakir, .et al. Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity, Nat Metab, 2022, Jan;4(1):44-59 PMID: 35039672
Isin Cakir, .et al. Sulforaphane reduces obesity by reversing leptin resistance, Elife, 2022, Mar 24 PMID: 35323110

Technical details

Catalog Num	A11042
M. Wt	371.9
Formula	C20H21N3O2.HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1310693-92-5, 1239262-52-2
Synonyms
SMILES	CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO.Cl

Biological Activity

Tubastatin A HCl是一种有效的选择性HDAC6抑制剂，在无细胞试验中IC50为15 nM。它对除HDAC8（57倍）以外的所有其他同工酶（1000倍）具有选择性。

Targets

Target	Value
HDAC6	IC50: 15nM
HDAC8	IC50: 854nM
HDAC1	IC50: 16.4μM
HDAC2	IC50: >30μM
HDAC3	IC50: >30μM
HDAC4	IC50: >30μM
HDAC5	IC50: >30μM
HDAC7	IC50: >30μM
HDAC9	IC50: >30μM
HDAC10	IC50: >30μM
HDAC11	IC50: >30μM

Solubility *

In vitro (25°C)	DMSO	67 mg/mL (180.17 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+40%PEG300+5%Tween80+50%ddH2O	5.2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.89 mL	134.44 mL	268.89 mL
0.5 mM	5.38 mL	26.89 mL	53.78 mL
1 mM	2.69 mL	13.44 mL	26.89 mL
5 mM	0.54 mL	2.69 mL	5.38 mL

*The above data is based on the productmolecular weight 371.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.