Flavopiridol HCl

Catalog No. A11045

Flavopiridol HCl是细胞周期蛋白依赖性激酶的抑制剂。(-)-顺式形式诱导特定肿瘤细胞的凋亡。
Catalog Num A11045
M. Wt 438.3
Formula C21H20ClNO5.HCl
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 131740-09-5
Synonyms
SMILES CN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl
Flavopiridol HCl是细胞周期蛋白依赖性激酶的抑制剂。(-)-顺式形式诱导特定肿瘤细胞的凋亡。
Targets
CDK1 (Cell-free assay) CDK2 (Cell-free assay) CDK4 (Cell-free assay) CDK6 (Cell-free assay) CDK7 (Cell-free assay)
40 nM40 nM40 nM40 nM300 nM
In vitro (25°C) DMSO 78 mg/mL (177.96 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.82 mL 114.08 mL 228.15 mL
0.5 mM 4.56 mL 22.82 mL 45.63 mL
1 mM 2.28 mL 11.41 mL 22.82 mL
5 mM 0.46 mL 2.28 mL 4.56 mL

*The above data is based on the productmolecular weight 438.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.