CHIR-124

Catalog No. A11046

CHIR-124是一种新型有效的Chk1抑制剂（Chk1和Chk2的IC50：分别为0.32 nM和697 nM）。

Technical details

Catalog Num	A11046
M. Wt	419.9
Formula	C23H22ClN5O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	405168-58-3
Synonyms	CHIR124
SMILES	C1CN2CCC1[C@@H](C2)NC3=C4C=C(C=CC4=NC(=O)C3=C5NC6=CC=CC=C6N5)Cl

Biological Activity

CHIR-124是一种新型有效的Chk1抑制剂（Chk1和Chk2的IC50：分别为0.32 nM和697 nM）。

Targets

Target	Value
Chk1	IC50: 0.3nM
FLT3	IC50: 5.8nM
PDGFR	IC50: 6.6nM
GSK-3	IC50: 23.3nM
Fyn	IC50: 98.8nM
PKA	IC50: 103.1nM
PKCγ	IC50: 110nM
LCK	IC50: 158.3nM
CDK2/CyclinA	IC50: 191.1nM
VEGFR1/FLT1	IC50: 463.6nM
Cdc2/CyclinB	IC50: 505.7nM
VEGFR2/Flk1	IC50: 577.9nM
PKCβ2	IC50: 580nM
PKCα	IC50: 580nM
Chk2	IC50: 697.4nM
FGFR3	IC50: 1.29μM
bFGFR	IC50: 2.04μM
CDK4/CyclinD	IC50: 2.05μM
PKAβ1	IC50: 2.25μM
c-Met	IC50: >3μM
ERK2	IC50: 4.31μM
CABL	IC50: 14.88μM

Solubility *

In vitro (25°C)	DMSO	6 mg/mL (14.29 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.82 mL	119.08 mL	238.15 mL
0.5 mM	4.76 mL	23.82 mL	47.63 mL
1 mM	2.38 mL	11.91 mL	23.82 mL
5 mM	0.48 mL	2.38 mL	4.76 mL

*The above data is based on the productmolecular weight 419.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.