PHA-848125 (Milciclib)

Catalog No. A11047

PHA-848125 (Milciclib)是一种有效的，ATP竞争性CDK抑制剂，作用于CDK2，IC50为45 nM，作用于CDK2比作用于CDK1，2，4，5和7选择性高3倍以上。

Technical details

Catalog Num	A11047
M. Wt	460.6
Formula	C25H32N8O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	802539-81-7
Synonyms	Milciclib, PHA848125
SMILES	CC1(CC2=CN=C(N=C2C3=C1C(=NN3C)C(=O)NC)NC4=CC=C(C=C4)N5CCN(CC5)C)C

Biological Activity

PHA-848125 (Milciclib)是一种有效的，ATP竞争性CDK抑制剂，作用于CDK2，IC50为45 nM，作用于CDK2比作用于CDK1，2，4，5和7选择性高3倍以上。

Targets

Target	Value
CDK2/CyclinA	IC50: 45nM
TrkA	IC50: 53nM
CDK7/CyclinH	IC50: 150nM
CDK4/CyclinD1	IC50: 160nM
CDK5/p35	IC50: 265nM
CDK2/CyclinE	IC50: 363nM
CDK1/CyclinB	IC50: 398nM

Solubility *

In vitro (25°C)	DMSO	91 mg/mL (197.58 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.71 mL	108.55 mL	217.11 mL
0.5 mM	4.34 mL	21.71 mL	43.42 mL
1 mM	2.17 mL	10.86 mL	21.71 mL
5 mM	0.43 mL	2.17 mL	4.34 mL

*The above data is based on the productmolecular weight 460.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.