OSI-027

Catalog No. A11056

OSI-027是一种有效的,选择性的,可口服生物利用的mTOR激酶抑制剂,可抑制与mTOR的TORC1和TORC2复合物相关的激酶活性。
Catalog Num A11056
M. Wt 406.4
Formula C21H22N6O3
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 936890-98-1
Synonyms OSI027
SMILES COC1=CC=CC2=C/C(=C/3\C4=C(N=CNN4C(=N3)C5CCC(CC5)C(=O)O)N)/N=C21
OSI-027是一种有效的,选择性的,可口服生物利用的mTOR激酶抑制剂,可抑制与mTOR的TORC1和TORC2复合物相关的激酶活性。
Targets
Target Value
mTORIC50: 4nM
mTORC1IC50: 22nM
mTORC2IC50: 65nM
PI3KγIC50: 0.42μM
DNA-PKIC50: 1.0μM
PI3KαIC50: 1.3μM
C-RafIC50: 1.6μM
YES1IC50: 2.8μM
EphA2IC50: 4.5μM
BTKIC50: 5.0μM
LCKIC50: 9.5μM
ACK1IC50: >10μM
p38αIC50: 10.6μM
KDRIC50: 19.0μM
PI3KβIC50: >30μM
IGF-1RIC50: >30μM
Insulin ReceptorIC50: >30μM
PDK-1IC50: >30μM
PKAIC50: >30μM
EGFR/ErbB1IC50: >30μM
MST1RIC50: >30μM
SrcIC50: >30μM
MEK1IC50: >30μM
FynIC50: >30μM
In vitro (25°C) DMSO 16 mg/mL (39.36 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.61 mL 123.03 mL 246.06 mL
0.5 mM 4.92 mL 24.61 mL 49.21 mL
1 mM 2.46 mL 12.3 mL 24.61 mL
5 mM 0.49 mL 2.46 mL 4.92 mL

*The above data is based on the productmolecular weight 406.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.