SB 415286

Catalog No. A11061

SB 415286是一种有效且具有选择性的细胞渗透性ATP竞争性GSK3α抑制剂，IC50值为78 nM（与GSK3β相似的效价），Ki值为31 nM。

Technical details

Catalog Num	A11061
M. Wt	359.7
Formula	C16H10ClN3O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	264218-23-7
Synonyms	SB-415286, SB415286
SMILES	C1=CC=C(C(=C1)C2=C(C(=O)NC2=O)NC3=CC(=C(C=C3)O)Cl)[N+](=O)[O-]

Biological Activity

SB 415286是一种有效且具有选择性的细胞渗透性ATP竞争性GSK3α抑制剂，IC50值为78 nM（与GSK3β相似的效价），Ki值为31 nM。

Targets

GSK-3α	GSK-3β
78 nM	~78 nM

Solubility *

In vitro	DMSO	63 mg/mL (175.13 mM)
	Water	Insoluble
	Ethanol	63 mg/mL (175.13 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.8 mL	139 mL	278.01 mL
0.5 mM	5.56 mL	27.8 mL	55.6 mL
1 mM	2.78 mL	13.9 mL	27.8 mL
5 mM	0.56 mL	2.78 mL	5.56 mL

*The above data is based on the productmolecular weight 359.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.