AZ628

Catalog No. A11063

AZ628是一种RAF抑制剂，IC50值：BRAF V600E和野生型CRAF约为30 nM，野生型BRAF约为100 nM。

Technical details

Catalog Num	A11063
M. Wt	451.5
Formula	C27H25N5O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	878739-06-1
Synonyms	AZ-628
SMILES	CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C

Biological Activity

AZ628是一种RAF抑制剂，IC50值：BRAF V600E和野生型CRAF约为30 nM，野生型BRAF约为100 nM。

Targets

C-Raf-1 (Cell-free assay)	B-Raf (V600E) (Cell-free assay)	B-Raf (Cell-free assay)
29 nM	34 nM	105 nM

Solubility *

In vitro (25°C)	DMSO	80 mg/mL (177.17 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+40% PEG 300+2% Tween 80+ddH2O	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.15 mL	110.74 mL	221.48 mL
0.5 mM	4.43 mL	22.15 mL	44.3 mL
1 mM	2.21 mL	11.07 mL	22.15 mL
5 mM	0.44 mL	2.21 mL	4.43 mL

*The above data is based on the productmolecular weight 451.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.