S/GSK1349572 (Dolutegravir)

Catalog No. A11068

S/GSK1349572是有效的下一代HIV整合酶抑制剂，并通过60个整合酶突变分子克隆证实了优异的耐药性。

Product Citations

Lea El Khoury, .et al. Spectrometric and computational studies of the binding of HIV-1 integrase inhibitors to viral DNA extremities, PeerJ Preprints, 2019, 7:e27833v1

Technical details

Catalog Num	A11068
M. Wt	419.4
Formula	C20H19F2N3O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1051375-16-6
Synonyms	Dolutegravir, GSK-1349572
SMILES	C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O

Biological Activity

S/GSK1349572是有效的下一代HIV整合酶抑制剂，并通过60个整合酶突变分子克隆证实了优异的耐药性。

Targets

HIV integrase (Cell-free assay)
2.7 nM

Solubility *

In vitro	DMSO	Warmed: 71 mg/mL (169.3 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.84 mL	119.22 mL	238.44 mL
0.5 mM	4.77 mL	23.84 mL	47.69 mL
1 mM	2.38 mL	11.92 mL	23.84 mL
5 mM	0.48 mL	2.38 mL	4.77 mL

*The above data is based on the productmolecular weight 419.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.