A-769662

Catalog No. A11071

A-769662是AMP激活的蛋白激酶（AMPK）的新激活剂。

Product Citations

Daniel Missailidis, .et al. Dysregulated Provision of Oxidisable Substrates to the Mitochondria in ME/CFS Lymphoblasts, Int J Mol Sci., 2021, Feb; 22(4): 2046 PMID: 33669532
Lieberthal W, .et al. AMPK-mediated activation of Akt protects renal tubular cells from stress-induced apoptosis in vitro and ameliorates ischemic AKI in vivo, Am J Physiol Renal Physiol, 2019, 2019 PMID: 30995114
Kikuchi H, .et al. Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease, Kidney Int, 2018, Nov 13. pii: S0085-2538(18)30635-5 PMID: 30455054
Schneider H, .et al. AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle, Hypertension, 2015, Jul;66(1):108-16 PMID: 26034200

Technical details

Catalog Num	A11071
M. Wt	360.4
Formula	C20H12N2O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	844499-71-4
Synonyms	A769662
SMILES	C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O

Biological Activity

A-769662是AMP激活的蛋白激酶（AMPK）的新激活剂。

Targets

AMPK (Cell-free assay)	Fatty acid synthesis (Cell-free assay)
0.8 μM(EC50)	3.2 μM

Solubility *

In vitro (25°C)	DMSO	65 mg/mL (180.36 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.75 mL	138.73 mL	277.47 mL
0.5 mM	5.55 mL	27.75 mL	55.49 mL
1 mM	2.77 mL	13.87 mL	27.75 mL
5 mM	0.55 mL	2.77 mL	5.55 mL

*The above data is based on the productmolecular weight 360.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.