PF-04929113 (SNX-5422)

Catalog No. A11074

PF-04929113 (SNX-5422)是一种有效的，选择性的HSP90抑制剂，Kd为41 nM，且诱导Her-2降解，IC50为37 nM。

Product Citations

Henry Aceros, .et al. Celastrol-type HSP90 modulators allow for potent cardioprotective effects, Life Sci, 2019, 2019
Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113

Technical details

Catalog Num	A11074
M. Wt	521.5
Formula	C25H30F3N5O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	908115-27-5
Synonyms	PF04929113, SNX5422
SMILES	CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C

Biological Activity

PF-04929113 (SNX-5422)是一种有效的，选择性的HSP90抑制剂，Kd为41 nM，且诱导Her-2降解，IC50为37 nM。

Targets

HER2	HSP90
37 nM	41 nM(Kd)

Solubility *

In vitro (25°C)	DMSO	90 mg/mL (172.57 mM)
	Water	Insoluble
	Ethanol	4 mg/mL (7.66 mM)
In vivo	0.5% CMC+0.25% Tween 80	23 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.18 mL	95.88 mL	191.75 mL
0.5 mM	3.84 mL	19.18 mL	38.35 mL
1 mM	1.92 mL	9.59 mL	19.18 mL
5 mM	0.38 mL	1.92 mL	3.84 mL

*The above data is based on the productmolecular weight 521.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.