AZD4547

Catalog No. A11075

AZD4547是一种有效，选择性和口服活性的pan-FGFR抑制剂，对于FGFR1、2、3和4的IC50分别为0.2、2.5、1.8和165 nM。

Product Citations

Ryuma Tokunaga, .et al. Fibroblast growth factor receptor 2 expression, but not its genetic amplification, is associated with tumor growth and worse survival in esophagogastric junction adenocarcinoma, Oncotarget, 2016, Apr 12; 7(15): 19748-19761 PMID: 26933914
Mitsuko Kawano, .et al. FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling, Adv Radiat Oncol, 2016, Jul-Sep; 1(3): 170-181 PMID: 28740887

Technical details

Catalog Num	A11075
M. Wt	463.6
Formula	C26H33N5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1035270-39-3
Synonyms	AZD-4547
SMILES	C[C@@H]1CN(C[C@@H](N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC

Biological Activity

AZD4547是一种有效，选择性和口服活性的pan-FGFR抑制剂，对于FGFR1、2、3和4的IC50分别为0.2、2.5、1.8和165 nM。

Targets

Target	Value
FGFR1	IC50: 0.2nM
FGFR3	IC50: 1.8nM
FGFR2	IC50: 2.5nM
KDR	IC50: 24nM
FGFR4	IC50: 165nM
IGFR	IC50: 581nM
Axl	IC50: >2μM
CDK2	IC50: >10μM
FAK	IC50: >10μM
ROCK2	IC50: >50μM
Akt1	IC50: >100μM
ALK1	IC50: >100μM
p38	IC50: >100μM
PI3Kα	IC50: >100μM

Solubility *

In vitro (25°C)	DMSO	79 mg/mL (170.41 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.57 mL	107.85 mL	215.7 mL
0.5 mM	4.31 mL	21.57 mL	43.14 mL
1 mM	2.16 mL	10.79 mL	21.57 mL
5 mM	0.43 mL	2.16 mL	4.31 mL

*The above data is based on the productmolecular weight 463.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.