JTC-801

Catalog No. A11076

JTC-801是nociceptin receptor（也称为ORL-1受体）的选择性拮抗剂。

Product Citations

Lihao Gu, .et al. 10-Hydroxy-2-Decenoic Acid in Royal Jelly Extract Induced Both Filaggrin and Amino Acid in a Cultured Human Three-Dimensional Epidermis Model, Cosmetics, 2017, 4(4), 48
Toshio Yawata, .et al. Brain opioid and nociceptin receptors are involved in regulation of bombesin-induced activation of central sympatho-adrenomedullary outflow in the rat, Mol Cell Biochem, 2016, Jan;411(1-2):201-11 PMID: 26427671

Technical details

Catalog Num	A11076
M. Wt	448
Formula	C26H25N3O2.HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	244218-51-7
Synonyms	JTC801
SMILES	CCC1=CC=C(C=C1)OCC2=CC=CC=C2C(=O)NC3=CC4=C(C=C3)N=C(C=C4N)C.Cl

Biological Activity

JTC-801是nociceptin receptor（也称为ORL-1受体）的选择性拮抗剂。

Solubility *

In vitro (25°C)	DMSO	88 mg/mL (196.45 mM)
	Water	Insoluble
	Ethanol	30 mg/mL (66.97 mM)
In vivo	0.5% methylcellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.32 mL	111.61 mL	223.21 mL
0.5 mM	4.46 mL	22.32 mL	44.64 mL
1 mM	2.23 mL	11.16 mL	22.32 mL
5 mM	0.45 mL	2.23 mL	4.46 mL

*The above data is based on the productmolecular weight 448. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.