Anacetrapib (MK-0859)
Catalog No. A11084
Anacetrapib (MK-0859)是一种有效的，选择性，可逆的rhCETP和突变CETP(C13S)抑制剂，IC50分别为7.9 nM和11.8 nM，提高HDL-C，降低LDL-C，不提高醛固酮和血压。
| Catalog Num | A11084 |
|---|---|
| M. Wt | 637.5 |
| Formula | C30H25F10NO3 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 875446-37-0 |
| Synonyms | MK0859 |
| SMILES | C[C@H]1[C@H](OC(=O)N1CC2=C(C=CC(=C2)C(F)(F)F)C3=CC(=C(C=C3OC)F)C(C)C)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F |
Anacetrapib (MK-0859)是一种有效的，选择性，可逆的rhCETP和突变CETP(C13S)抑制剂，IC50分别为7.9 nM和11.8 nM，提高HDL-C，降低LDL-C，不提高醛固酮和血压。
| In vitro (25°C) | DMSO | 108 mg/mL (169.41 mM) | |
| Water | Insoluble | ||
| Ethanol | 108 mg/mL (169.41 mM) | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.69 mL | 78.43 mL | 156.86 mL |
| 0.5 mM | 3.14 mL | 15.69 mL | 31.37 mL |
| 1 mM | 1.57 mL | 7.84 mL | 15.69 mL |
| 5 mM | 0.31 mL | 1.57 mL | 3.14 mL |
*The above data is based on the productmolecular weight 637.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Contact information
United StatesAdooq Bioscience
Toll Free: (866) 930-6790
Fax: +1-323-606-8156
Email: sales@adooq.com
ADOOQ 产品质量保证
We promise all products to perform as described.