CHIR-98014

Catalog No. A11085

CHIR-98014是一种非常有效的，选择性的，细胞可渗透的GSK-3抑制剂。

Technical details

Catalog Num	A11085
M. Wt	486.3
Formula	C20H17Cl2N9O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	252935-94-7
Synonyms	CHIR98014
SMILES	C1=CC(=C(C=C1Cl)Cl)C2=NC(=NC=C2N3C=CN=C3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N

Biological Activity

CHIR-98014是一种非常有效的，选择性的，细胞可渗透的GSK-3抑制剂。

Targets

Target	Value
GSK-3β	IC50: 0.58nM
GSK-3α	IC50: 0.65nM
p70S6K	IC50: >1μM
c-Src	IC50: >1μM
bFGFR	IC50: >1μM
KDR	IC50: >2μM
IGF-1R	IC50: >2μM
Insulin Receptor	IC50: >2μM
Cdc2	IC50: 3.7μM
Akt1	IC50: >5μM
Tie-2	IC50: >5μM
FLT1	IC50: >5μM
CK1ε	IC50: >5μM
ERK2	IC50: >10μM
PKCα	IC50: >10μM
p90RSK2	IC50: >10μM
Chk1	IC50: >10μM
DNA-PK	IC50: >10μM
PI3K	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 7 mg/mL (14.39 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+corn oil	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.56 mL	102.82 mL	205.63 mL
0.5 mM	4.11 mL	20.56 mL	41.13 mL
1 mM	2.06 mL	10.28 mL	20.56 mL
5 mM	0.41 mL	2.06 mL	4.11 mL

*The above data is based on the productmolecular weight 486.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.