NU-7441 (KU-57788)

Catalog No. A11098

NU-7441 (KU-57788)是一种有效的选择性DNA依赖性蛋白激酶（DNA-PK）抑制剂。对于DNA-PK，mTOR，PI 3-K，ATM和ATR，IC50值分别为14、1700、5000，> 100000和> 100000 nM。

Product Citations

Shahar Biechonski, .et al. Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation, Sci Rep, 2018, Apr 17 PMID: 29666389
Ihara M, .et al. Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines, J Radiat Res, 2018, Nov 23 PMID: 30476230
Chwastek J, .et al. The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D, Int J Biochem Cell Biol, 2017, Jun;87:38-53 PMID: 28341201
Masaaki Yanai, .et al. DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair, Yonago Acta Med, 2017, Mar; 60(1): 9-15 PMID: 28331416

Technical details

Catalog Num	A11098
M. Wt	413.5
Formula	C25H19NO3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	503468-95-9
Synonyms	NU7441, KU57788
SMILES	C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56

Biological Activity

NU-7441 (KU-57788)是一种有效的选择性DNA依赖性蛋白激酶（DNA-PK）抑制剂。对于DNA-PK，mTOR，PI 3-K，ATM和ATR，IC50值分别为14、1700、5000，> 100000和> 100000 nM。

Solubility *

In vitro (25°C)	DMSO	Warmed: 4 mg/mL (9.67 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+5% Tween 80+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.18 mL	120.92 mL	241.84 mL
0.5 mM	4.84 mL	24.18 mL	48.37 mL
1 mM	2.42 mL	12.09 mL	24.18 mL
5 mM	0.48 mL	2.42 mL	4.84 mL

*The above data is based on the productmolecular weight 413.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.