PU-H71

Catalog No. A11130

PU-H71是有效的Hsp90抑制剂(IC50 = 50 nM)。
  • Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
  • Kale S, .et al. HSP90 inhibitor PU-H71 increases radiosensitivity of breast cancer cells metastasized to visceral organs and alters the levels of inflammatory mediators, Naunyn Schmiedebergs Arch Pharmacol, 2019, Sep 14 PMID: 31522240
  • Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
Catalog Num A11130
M. Wt 512.37
Formula C18H21IN6O2S
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 873436-91-0
Synonyms PUH71
SMILES CC(C)NCCCN1C2=C(C(=NC=N2)N)N=C1SC3=C(C=C4C(=C3)OCO4)I
PU-H71是有效的Hsp90抑制剂(IC50 = 50 nM)。
Targets
HSP90
51 nM
In vitro DMSO 86 mg/mL (167.85 mM)
Water Warmed: 29 mg/mL (56.59 mM)
Ethanol 86 mg/mL (167.85 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.52 mL 97.59 mL 195.17 mL
0.5 mM 3.9 mL 19.52 mL 39.03 mL
1 mM 1.95 mL 9.76 mL 19.52 mL
5 mM 0.39 mL 1.95 mL 3.9 mL

*The above data is based on the productmolecular weight 512.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.