CH5424802

Catalog No. A11134

CH5424802是一种有效的，选择性的，口服的ALK抑制剂，具有独特的化学支架，对具有ALK基因改变的癌症表现出优先的抗肿瘤活性。

Technical details

Catalog Num	A11134
M. Wt	482.6
Formula	C30H34N4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1256580-46-7
Synonyms	CH-5424802
SMILES	CCC1=C(C=C2C(=C1)C(=O)C3=C(C2(C)C)NC4=C3C=CC(=C4)C#N)N5CCC(CC5)N6CCOCC6

Biological Activity

CH5424802是一种有效的，选择性的，口服的ALK抑制剂，具有独特的化学支架，对具有ALK基因改变的癌症表现出优先的抗肿瘤活性。

Targets

Target	Value
ALK(F1174L)	IC50: 1nM
ALK	IC50: 1.9nM
ALK(R1275Q)	IC50: 3.5nM
INSR	IC50: 550nM
KDR	IC50: 1.4μM
Abl	IC50: >5μM
EGFR	IC50: >5μM
FGFR2	IC50: >5μM
HER2	IC50: >5μM
IGF-1R	IC50: >5μM
JAK1	IC50: >5μM
Kit	IC50: >5μM
Met	IC50: >5μM
PDGFRβ	IC50: >5μM
Src	IC50: >5μM
Akt1	IC50: >5μM
Akt2	IC50: >5μM
Akt3	IC50: >5μM
AuroraA	IC50: >5μM
CDK1	IC50: >5μM
CDK2	IC50: >5μM
MEK1	IC50: >5μM
PKA	IC50: >5μM
PKCα	IC50: >5μM
PKCβ1	IC50: >5μM
PKCβ2	IC50: >5μM
Raf-1	IC50: >5μM

Solubility *

In vitro	DMSO	Warmed: 0.5 mg/mL (1.03 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.72 mL	103.61 mL	207.21 mL
0.5 mM	4.14 mL	20.72 mL	41.44 mL
1 mM	2.07 mL	10.36 mL	20.72 mL
5 mM	0.41 mL	2.07 mL	4.14 mL

*The above data is based on the productmolecular weight 482.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.